Comparative Effectiveness Research
Comparative Effectiveness Research (CER) compares available treatment options utilizing a range of research methods including randomized controlled trials, observational studies, and systematic reviews, a structured assessment of evidence available from multiple primary studies.
The foundation for CER is evidence-based medicine, which is a systematic approach to clinical problem solving which allows the integration of the best available research evidence with clinical expertise and patient values.
Patient Protection and Affordable Care Act of 2010
In the health care reform law, the “Patient Protection and Affordable Care Act of 2010,” CER is positioned to support the development of comparative evidence that will better inform health care decision-making; however, many questions remain about how the new law will be implemented.
The American Recovery and Reinvestment Act of 2009 (ARRA) provided $1.1 billion in new public funds for CER and set in motion a series of activities including the development of federal priorities for CER and efforts to enhance the nation’s research infrastructure to conduct CER in “real world” settings.
Patient-Centered Outcomes Research Institute
To help manage and augment the new public focus on CER, the 2010 health care reform law creates the non-profit Patient-Centered Outcomes Research Institute (PCORI) that is not an agency of government, but rather an independent organization with a multi-stakeholder Board of Governors and sustained public-private funding for CER that will reach nearly $650 million by 2014. (See NPC's Patient-Centered Outcomes Research Institute (PCORI) Resource Guide for details).
Moving forward, it is critical to establish the right guiding principles that will be used by decision-makers in determining CER priorities, which can play a critical role in improving patient health outcomes in the future.
Ultimately, it is the patients who will benefit under a healthcare system where sound evidence is recognized by independent experts, considered appropriately by plans, reflected adequately in benefit design, and incorporated into clinical decision-making.
- April 30, 2012- NPC Comments on Addenda to AMCP Format for Formulary Submissions
- March 15, 2012- NPC Comments on PCORI Draft National Priorities and Research Agenda
- February 29, 2012- Asymmetry in the Ability to Communicate CER Findings
- January 18, 2012- NPC Commentary Before the Patient-Centered Outcomes Research Institute
- January 2, 2012- CER and the Changing Health Care Landscape
- November 29, 2011- CER-Who Can Say What and When Can They Say It
- October 27, 2011- CER Done Right--Why It Matters
- September 27, 2011- A Look at PCORI, One Year Later
- September 2, 2011- NPC Comments on the Patient-Centered Outcomes Research Definition
- August 29, 2011- Medicare Part D, Adherence, and the Value of Pharmaceuticals
- July 27, 2011- Linking Chronic Conditions to Medication Adherence and Productivity
- June 28, 2011- Comparative Effectiveness Research: What Will Employers Do With the Information?
- May 27, 2011- Questions Abound on the Adoption of Evidence
- April 28, 2011- Message: Proposed ACO Rules Raising More Questions Than Answers
- March 29, 2011- Message: Moving from 'Comparative' to 'Effectiveness' in Health Care Treatments
- February 28, 2011- Message: Synergies at Work: Realizing the Full Value of Health Investments
- January 31, 2011- Message: What Will 2011 Hold for CER and PCORI
- December 20, 2010- NPC Reflects on Changes in 2010
- November 29, 2010- The Role of the PCORI Methodology Committee
- October 28, 2010- Health Affairs CER Briefing Highlights Key Issues
- October 28, 2010- A Busy Time for CER
- September 30, 2010- PCORI Board of Governors to Begin Work
- August 9, 2010 - Comments on Request for Information for Development of CER Inventory
- May 3, 2010 - Time for PCORI’s Implementation
- January 29, 2010 - Health Care Reform and a CER Entity: Will It Happen?
- June 10, 2009 - NPC Testimony submitted to the Federal Coordinating Council on Comparative Effectiveness Research on the Draft Definition and Strategic Framework for Comparative Effectiveness Research
- April 2009 – It’s Important to Get CER Right, commentary from NPC President Dan Leonard
- April 14, 2009 - NPC Testimony before the Federal Coordinating Council on Comparative Effectiveness Research
- April 3, 2009 - NPC Testimony before the Agency for Healthcare Research and Quality
- March 20, 2009 - NPC Testimony before the Institute of Medicine Comparative Effectiveness Research Committee
- March 27, 2012- NPC Survey of Health Care Stakeholders Indicates Cautious Optimism About Use of CER
- February 6, 2012- NPC Conference to Address Questions on Ability to Share Health Research Findings
- January 30, 2012- NPC Selects Five Research Projects for Funding
- January 20, 2012- NPC Debuts Column in New Journal of Comparative Effectiveness Research
- January 4, 2012- National Pharmaceutical Council Expands Policy and Research Staff
- December 5, 2011- NPC Examines Optimal Process for Prioritizing Comparative Effectiveness Research
- October 28, 2011- AstraZeneca’s Rich Fante Elected as National Pharmaceutical Council’s Chairman of the Board
- August 3, 2011- NPC Welcomes Shire as Its Newest Member
- June 22, 2011- New Survey Shows Employers Eyeing CER and PCORI for Health Information
- June 16, 2011- Study Sheds New Light on the Impact of Medication Adherence, Multiple Chronic Diseases and Health Risks in the Workplace
- May 16, 2011- NPC Congratulates Dr Selby as PCORI Executive Director
- May 2, 2011- Stakeholder Survey Shows Comparative Effectiveness Research Development Heading in Right Direction
- Februaury 28, 2011- New Report Urges Employers, Researchers and Policy Makers to Rethink How They Measure Health Care Results
- January 21, 2011 - NPC Comments on PCORI Methodology Committee Appointments
- September 23, 2010 - NPC Comments on Patient-Centered Outcomes Research Institute Board of Governors
- March 25, 2010 - NPC Pleased With Establishment of Patient Centered Outcomes Research Institute
- December 10, 2009 - New NPC Report Provides Guidance on Evaluating and Interpreting Comparative Effectiveness Studies
- November 17, 2009 - Avalere Explores Impact of Comparative Effectiveness Research on Healthcare Innovation
- October 27, 2009 - Leaders in Healthcare to Examine Impact of Comparative Effectiveness Research on Personalized Medicine
- September 10, 2009 - NPC Response to President Obama's Health Care Address to Congress
- September 16, 2009 - NPC Commends Senate Finance Committee Chairman Baucus for Comparative Effectiveness Research Provisions in Chairman's Mark
- June 17, 2009 - NPC Says Comparative Effectiveness Can Improve Patient Outcomes
- February 17, 2009 - NPC Statement on Economic Stimulus Package