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Demystifying Comparative Effectiveness Research: A Case Study Learning Guide

This report, “Demystifying Comparative Effectiveness Research: A Case Study Learning Guide,” written by Robert W. Dubois, MD, PhD, chief medical officer of Cerner LifeSciences, and Sylvia L. Kindermann, MPH, Cerner LifeSciences senior research associate, discusses the three most prominent types of CER:

  • Randomized controlled trials (RCTs), wherein subjects in a population are randomly allocated into study and control groups to receive or not to receive an experimental intervention, such as a new therapeutic biopharmaceutical or medical device;
  • Meta-analysis, which synthesizes data across a series of similar studies, generally RCTs; and
  • Observational studies, which follow participants over a period of time to examine the potential associations between patients’ exposure to treatment and health outcomes.

The report details a guide on how to best evaluate each kind of study, and it discusses case studies in each of the three types of CER.

An executive summary of this report is also available.

Newsletter Volume

E.V.I.dently June 2015

NPC MessageDriving Health System Value Through Broader Access to DataFrom Fitbits to insurance claims databases, we capture an enormous amount of...
Blog Post

NPC Comments on ASCO Value Framework

The American Society of Clinical Oncology (ASCO) on Monday released a conceptual framework--“A Framework to Assess the Value of Cancer Treatment...
Blog Post

CER Tweets of the Week: CER in the New York Times, AcademyHealth’s Stakeholder Engagement Resources (June 8-12)

This week, comparative effectiveness research (CER) stakeholders shared a @Health_Affairs blog post on how CER can help institutional review boards...
Blog Post

CER Tweets of the Week: CMS at Health Datapalooza, #ASCO15 (June 1-5)

This week, comparative effectiveness research (CER) stakeholders tweeted the Centers for Medicare and Medicaid Services’ (@CMSGov) announcement...
Press Release

NPC Comments on CMS’ Announcement to Allow Broader Access to Publicly Funded Databases

(Washington, DC, June 2, 2015)—The National Pharmaceutical Council (NPC) today commented on the Centers for Medicare and Medicaid Services’ (CMS)...
Press Release

State Medicaid Directors Share Views on Comparative Effectiveness Research And Its Impact on Policy in National Pharmaceutical Council Survey

(Washington, DC, April 16, 2015)—A new survey conducted on behalf of the National Pharmaceutical Council (NPC) shows that state Medicaid directors...
Press Release

NPC Highlights Stakeholder Views on Comparative Effectiveness Research and the Environment for Health Care Decision-Making

(Washington, DC, March 26, 2015)—A new survey of health care stakeholders reveals continued optimism that comparative effectiveness research (CER)...
Press Release

NPC Study Outlines When & How Health Decision-Makers Should Consider Individual Patient Differences

Washington, DC (July 29, 2014)—New research led by the National Pharmaceutical Council (NPC) can assist health care stakeholders to understand when...
Commentary and Testimony Page

Chain Drug Review – Commentary: “Health Care Outlook for 2015”

This commentary was originally published in the January 5, 2015 issue of Chain Drug Review.By: Dan Leonard, President, National Pharmaceutical...
Commentary and Testimony Page

NPC Comments on PCORI Proposal for Peer Review of Primary Research and Public Release of Research Findings

November 7, 2014Dr. Joe SelbyExecutive DirectorPatient-Centered Outcomes Research Institute1828 L St., NW, Suite 900Washington, DC 20036Dear Dr....
Commentary and Testimony Page

The State of CER and the Environment for Health Care Decision Making

This month, NPC released its third annual survey on stakeholders’ views on comparative effectiveness research (CER), “The State of Comparative...
Commentary and Testimony Page

Keeping Our Eye on the CER Ball

Until the cherry blossoms begin to bloom later next month, most of the water cooler conversations in Washington will focus on the federal budget....
YouTube Videos

Comparative Effectiveness Research and the Environment for Health Care Decision-Making

During a March 26, 2015 webinar, the National Pharmaceutical Council discussed the results of its annual stakeholder survey on comparative...
YouTube Videos

Real-World Impact of Comparative Effectiveness Research Findings on Clinical Practice

National Pharmaceutical Council Chief Science Officer Robert W. Dubois, MD, PhD, discusses a peer-reviewed study suggesting that changes are needed...
YouTube Videos

Using Real-World Evidence to Increase Health Care Access, Improve Quality & Reduce Costs

Mitchell Sugarman, vice president of health economics, policy and payment at Medtronic Cardiac and Vascular Group, explains that health care decision...
YouTube Videos

CER and the Environment for Health Care Decision-Making

The National Pharmaceutical Council’s (NPC) fourth annual survey of health care stakeholders is continuing to shed light on the current environment...
Blog Post

NPC Comments on ASCO Value Framework

The American Society of Clinical Oncology (ASCO) on Monday released a conceptual framework--“A Framework to Assess the Value of Cancer Treatment...
Blog Post

CER Tweets of the Week: CER in the New York Times, AcademyHealth’s Stakeholder Engagement Resources (June 8-12)

This week, comparative effectiveness research (CER) stakeholders shared a @Health_Affairs blog post on how CER can help institutional review boards...
Blog Post

CER Tweets of the Week: CMS at Health Datapalooza, #ASCO15 (June 1-5)

This week, comparative effectiveness research (CER) stakeholders tweeted the Centers for Medicare and Medicaid Services’ (@CMSGov) announcement...
Blog Post

CER Tweets of the Week: NPC’s Dr. Dubois in JCER, AcademyHealth’s Data Quality Collaborative Projects (May 25-29)

This week, comparative effectiveness research (CER) stakeholders tweeted the latest column from National Pharmaceutical Council (@npcnow) Chief...
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