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Demystifying Comparative Effectiveness Research: A Case Study Learning Guide

This report, “Demystifying Comparative Effectiveness Research: A Case Study Learning Guide,” written by Robert W. Dubois, MD, PhD, chief medical officer of Cerner LifeSciences, and Sylvia L. Kindermann, MPH, Cerner LifeSciences senior research associate, discusses the three most prominent types of CER:

  • Randomized controlled trials (RCTs), wherein subjects in a population are randomly allocated into study and control groups to receive or not to receive an experimental intervention, such as a new therapeutic biopharmaceutical or medical device;
  • Meta-analysis, which synthesizes data across a series of similar studies, generally RCTs; and
  • Observational studies, which follow participants over a period of time to examine the potential associations between patients’ exposure to treatment and health outcomes.

The report details a guide on how to best evaluate each kind of study, and it discusses case studies in each of the three types of CER.

An executive summary of this report is also available.

Newsletter Volume

E.V.I.dently December 2014

NPC MessageHave a Great Research Idea? We Might Have a Grant for That.When we hear from a wide range of health care stakeholders, it provides us with...
Blog Post

CER Tweets of the Week: CMS Proposing Rule to Improve ACOs, PCORI Funds Hepatitis C Research (December 8-12)

This week, comparative effectiveness research (CER) stakeholders tweeted news about two entities that resulted from the Affordable Care Act—...
Blog Post

CER Tweets of the Week: NPC Launches New RFP for Innovative Research, PCORI Opens Comment Period on Research D&I Framework & Toolkit (December 1-5)

This week, comparative effectiveness research (CER) stakeholders tweeted about research opportunities. AcademyHealth’s EDM Forum (@edm_ah) shared the...
Blog Post

CER Tweets of the Week: Input on PCORI Workshop, CER Collaborative Resources (November 24-28)

What are comparative effectiveness research (CER) stakeholders tweeting about? The Patient-Centered Outcomes Research Institute (@PCORI) asked for...
Press Release

NPC Study Outlines When & How Health Decision-Makers Should Consider Individual Patient Differences

Washington, DC (July 29, 2014)—New research led by the National Pharmaceutical Council (NPC) can assist health care stakeholders to understand when...
Press Release

NPC Annual Stakeholder Survey: Comparative Effectiveness Research Is Important, But Impact on Health Care Decision-Making Is Still on the Horizon

(Washington, DC, May 19, 2014)—A new survey of health care stakeholders reveals continued optimism for the use of comparative effectiveness research...
Press Release

CER Collaborative Improving Health Outcomes Through New Comparative Evidence Tools

(Washington, DC, March 24, 2014)—Three peer-reviewed articles published in Value in Health offer important guidance to aid formulary decision-makers...
Press Release

NPC, Quintiles Study Tests Tools to Evaluate Quality of Observational Research in Comparative Effectiveness Studies

(Washington, DC, February 25, 2014)—With the growing demand for information about comparative effectiveness and questions about the quality of...
Commentary and Testimony Page

NPC Comments on PCORI Proposal for Peer Review of Primary Research and Public Release of Research Findings

November 7, 2014Dr. Joe SelbyExecutive DirectorPatient-Centered Outcomes Research Institute1828 L St., NW, Suite 900Washington, DC 20036Dear Dr....
Commentary and Testimony Page

The State of CER and the Environment for Health Care Decision Making

This month, NPC released its third annual survey on stakeholders’ views on comparative effectiveness research (CER), “The State of Comparative...
Commentary and Testimony Page

Keeping Our Eye on the CER Ball

Until the cherry blossoms begin to bloom later next month, most of the water cooler conversations in Washington will focus on the federal budget....
Commentary and Testimony Page

Leveling the Playing Field? Could a Landmark Decision Alter the CER Communications Landscape?

A growing chorus of voices is publicly sharing data on the effectiveness of treatment options, but one viewpoint has long been shut out of key areas...
YouTube Videos

Real-World Impact of Comparative Effectiveness Research Findings on Clinical Practice

National Pharmaceutical Council Chief Science Officer Robert W. Dubois, MD, PhD, discusses a peer-reviewed study suggesting that changes are needed...
YouTube Videos

Using Real-World Evidence to Increase Health Care Access, Improve Quality & Reduce Costs

Mitchell Sugarman, vice president of health economics, policy and payment at Medtronic Cardiac and Vascular Group, explains that health care decision...
YouTube Videos

CER and the Environment for Health Care Decision-Making

The National Pharmaceutical Council’s (NPC) fourth annual survey of health care stakeholders is continuing to shed light on the current environment...
YouTube Videos

Webinar: CER Collaborative: Tools You Can Use

Collaborative members hosted a webinar explaining how to use the tools they developed to create greater uniformity and transparency when evaluating...
Blog Post

CER Tweets of the Week: CMS Proposing Rule to Improve ACOs, PCORI Funds Hepatitis C Research (December 8-12)

This week, comparative effectiveness research (CER) stakeholders tweeted news about two entities that resulted from the Affordable Care Act—...
Blog Post

CER Tweets of the Week: NPC Launches New RFP for Innovative Research, PCORI Opens Comment Period on Research D&I Framework & Toolkit (December 1-5)

This week, comparative effectiveness research (CER) stakeholders tweeted about research opportunities. AcademyHealth’s EDM Forum (@edm_ah) shared the...
Blog Post

CER Tweets of the Week: Input on PCORI Workshop, CER Collaborative Resources (November 24-28)

What are comparative effectiveness research (CER) stakeholders tweeting about? The Patient-Centered Outcomes Research Institute (@PCORI) asked for...
Blog Post

CER Tweets of the Week: PCORI’s Selby to Speak at CTSI Symposium, PIPC Annual Forum; Cochrane Consumer Network Training (November 17-21)

Upcoming and past events garnered attention among comparative effectiveness research (CER) stakeholders this week. They tweeted about the University...

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Commentary & Testimony