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Racial and Ethnic Differences in Response to Medicines: Towards Individualized Pharmaceutical Treatment

Recognizing that substantial disparities exist in the quality and quantity of medical care received by minority Americans, especially those of African, Asian and Hispanic heritage, this article reviews the genetic factors that underlie varying responses to medicines observed among different ethnic and racial groups. Pharmacogenetic research in the past few decades has uncovered significant differences among racial and ethnic groups in the metabolism, clinical effectiveness, and side-effect profiles of many clinically important drugs. The authors suggest that these differences must be taken into account in the design of cost management policies such as formulary implementation, therapeutic substitution and step-care protocols. They also suggest that these programs should be broad and flexible enough to enable rational choices and individualized treatment for all patients, regardless of race or ethnic origin.

Blog Post

#TBT: Enrollment Deadline & the Role of Rx in Health Exchanges

As part of our “Throwback Thursday” blog series, we’re taking a look at a research topic that’s currently in the news and tagging it with...
Commentary and Testimony Page

NPC Comments on CMS' Proposed Changes to Protected Classes

March 7, 2014Marilyn B. TavennerAdministratorCenters for Medicare & Medicaid ServicesU.S. Department of Health and Human Services200 Independence...
Blog Post

NPC Asks CMS to Consider Patients’ Individual Treatment Effects In Part D Rulemaking

The National Pharmaceutical Council (NPC) today asked the Centers for Medicare and Medicaid Services (CMS) to consider maintaining “protected classes...
Newsletter Volume

E.V.I.dently February 2014

Message From NPCAs PCORI Funds Head-to-Head Comparisons, Research Must Remain Meaningful, TransparentIn the years since its establishment, the...
Press Release

NPC, UMD Study: Factors That Cause Different Treatment Responses Are Not Well Understood or Studied

Washington, DC, November 4, 2013—Although researchers and health care providers widely recognize that individuals with stage IV prostate cancer react...
Press Release

National Pharmaceutical Council Comments on PCORI Approval of Research Methodology Standards

Washington, DC (November 19, 2012)—The National Pharmaceutical Council (NPC) today commented on the Patient-Centered Outcomes Research Institute’s (...
Press Release

Leading Researchers Outline Principles for Conduct of Comparative Effectiveness Research

WASHINGTON, DC (September 11, 2012)—A new set of principles developed by a group of leading researchers could help to ensure more consistency in how...
Press Release

Pharmaceuticals Play Key Role in Achieving ACO Quality, Cost Goals

WASHINGTON, DC, July 18, 2012–As health care providers set up accountable care organizations (ACOs) and other value-based care programs,...
Commentary and Testimony Page

NPC Comments on CMS' Proposed Changes to Protected Classes

March 7, 2014Marilyn B. TavennerAdministratorCenters for Medicare & Medicaid ServicesU.S. Department of Health and Human Services200 Independence...
Commentary and Testimony Page

Leveling the Playing Field? Could a Landmark Decision Alter the CER Communications Landscape?

A growing chorus of voices is publicly sharing data on the effectiveness of treatment options, but one viewpoint has long been shut out of key areas...
Commentary and Testimony Page

The Risks of Standardized Health Care

Think about the last time you visited a medical office. Even at a specialist’s office, chances are that each person waiting for his or her name to be...
Commentary and Testimony Page

Framework Helps ACOs Leverage Pharmaceuticals to Realize Quality, Cost Goals

Medications are more than an item on the balance sheet for health care providers. Pharmaceuticals offer a route to manage costs while achieving...
YouTube Videos

Using Distributed Data Networks to Understand Heterogeneity in Real-World Data

Kimberly Westrich, director of health services research at the National Pharmaceutical Council, explains how large observational datasets like...
YouTube Videos

Understanding Individual Patients' Health Care Needs

Paul Martino, SVP of Clinical Strategy and Innovation at WellPoint, Inc., explains that it's important for payers and other health care stakeholders...
YouTube Videos

Taking Patient Variations Into Account

Dr. Lisa Egbuonu-Davis, founder of ROI Squared, explains that data is generally designed toward looking at the mean differences instead of the...
YouTube Videos

Payer Views of Individualized Health Care

Dr. Daniel Malone, professor at the University of Arizona School of Pharmacy, explains how payers view the issue of individualized therapy. He says...
Blog Post

#TBT: Enrollment Deadline & the Role of Rx in Health Exchanges

As part of our “Throwback Thursday” blog series, we’re taking a look at a research topic that’s currently in the news and tagging it with...
Blog Post

NPC Asks CMS to Consider Patients’ Individual Treatment Effects In Part D Rulemaking

The National Pharmaceutical Council (NPC) today asked the Centers for Medicare and Medicaid Services (CMS) to consider maintaining “protected classes...
Blog Post

Relationship Between Individual Patient Differences and Health Outcomes

Despite the widely accepted fact that a patient’s biologic (e.g., age, race, genetic factors) and nonbiologic factors (e.g., social behaviors,...
Blog Post

Four Online Seminars Focus on Impact of Individual Treatment Effects on Drug Therapy

Health care decision-makers interested in understanding how heterogeneity, or individual treatment effects, impact patient health outcomes will...

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