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Toward Individualized Pharmaceutical Care of East Asians

Research into the relationship between genetics and drug response has focused on polymorphisms, or variations, in genes that encode drug-metabolizing enzymes, particularly the genes that affect the clearance of the anticoagulant warfarin, proton pump inhibitors, tricyclic antidepressants, and many other clinically relevant drugs. Much of this work has targeted East Asians, a genetically distinguishable and populous group. Researchers have identified polymorphisms that inactivate gene function, compared polymorphism frequencies in East-Asian and Caucasian populations, and determined the effects on the pharmacokinetic parameters of drugs. Detection in an individual of polymorphisms known to inactivate a drug-metabolizing enzyme is predictive of poor metabolism of drugs processed by that pathway, which itself may be predictive of an atypical drug response. Genetic tests can be used to screen for individuals who are poor metabolizers, with the ultimate goal of better predicting the clinical effects of drugs.

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#TBT: 10 Prescribing Principles for Older Patients & #WHCOA

As part of our “Throwback Thursday” blog series, we’re taking a look at a topic that’s currently in the news and tagging it with previous...
Newsletter Volume

E.V.I.dently April 2015

MessageThe Health Care Paradigm Shift: Moving From Volume to ValueAs our health care payment and delivery systems shift from volume-based to...
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#TBT: Senior Citizens Day & Individualized Pharmaceutical Care

As part of our “Throwback Thursday” blog series, we’re taking a look at a topic that’s currently in the news and tagging it with previous...
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#TBT: Ethnic Disparities in the Burden and Treatment of Asthma

As part of our “Throwback Thursday” blog series, we’re taking a look at a topic that’s currently in the news and tagging it with previous...
Press Release

NPC, UMD Study: Factors That Cause Different Treatment Responses Are Not Well Understood or Studied

Washington, DC, November 4, 2013—Although researchers and health care providers widely recognize that individuals with stage IV prostate cancer react...
Press Release

Pharmaceuticals Play Key Role in Achieving ACO Quality, Cost Goals

WASHINGTON, DC, July 18, 2012–As health care providers set up accountable care organizations (ACOs) and other value-based care programs,...
Press Release

NPC, Health Industry Forum, AHIP and Blue Cross Blue Shield to Host Symposium, Shaping Convergent Strategies for Comparative Effectiveness Research

Washington, DC (June 21, 2010)—Dr. Janet Woodcock, director of the Center for Drug Evaluation and Research at the Food and Drug Administration, Dr....
Press Release

New Study Shows that Pharmacogenomics Could Benefit Patients, Spur Investment in Innovation

Washington, DC. (July 31, 2009) – A new study funded by the National Pharmaceutical Council (NPC) shows that pharmacogenomics – the field of...
Commentary and Testimony Page

Questions Abound on the Adoption of Evidence

Medical decision making should rely on evidence (when available) to ensure that treatments are appropriate and effective for patients. Given the...
Commentary and Testimony Page

Health Affairs CER Briefing Highlights Key Issues

Just one week after the appointment of the board of governors for the new comparative effectiveness research (CER) body, the Patient-Centered...
YouTube Videos

Taking Patient Variations Into Account

Dr. Lisa Egbuonu-Davis, founder of ROI Squared, explains that data is generally designed toward looking at the mean differences instead of the...
YouTube Videos

Understanding Individual Patients' Health Care Needs

Paul Martino, SVP of Clinical Strategy and Innovation at WellPoint, Inc., explains that it's important for payers and other health care stakeholders...
YouTube Videos

Dr. Allison-Ottey on Individualized Patient Care

Dr. Sharon Allison-Ottey, executive director of the COSHAR Foundation, explains that when it comes to ensuring optimal care for patients, all of...
YouTube Videos

Payer Views of Individualized Health Care

Dr. Daniel Malone, professor at the University of Arizona School of Pharmacy, explains how payers view the issue of individualized therapy. He says...
Blog Post

#TBT: 10 Prescribing Principles for Older Patients & #WHCOA

As part of our “Throwback Thursday” blog series, we’re taking a look at a topic that’s currently in the news and tagging it with previous...
Blog Post

#TBT: Senior Citizens Day & Individualized Pharmaceutical Care

As part of our “Throwback Thursday” blog series, we’re taking a look at a topic that’s currently in the news and tagging it with previous...
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#TBT: Ethnic Disparities in the Burden and Treatment of Asthma

As part of our “Throwback Thursday” blog series, we’re taking a look at a topic that’s currently in the news and tagging it with previous...
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#TBT: Enrollment Deadline & the Role of Rx in Health Exchanges

As part of our “Throwback Thursday” blog series, we’re taking a look at a research topic that’s currently in the news and tagging it with...

Ethnic Disparities in the Burden and Treatment of Asthma

This report, developed in partnership with the

Genes, Culture, and Medicines: Bridging Gaps in Treatment for Hispanic Americans

This report brings together for the first time a gro

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