NPC Request for Proposal for Innovative Research

About NPC’s Research

The National Pharmaceutical Council (NPC) is a policy research organization dedicated to the advancement of good evidence and science, and fostering an environment supporting innovation in the United States. The organization’s research focus is upon improving access to care by demonstrating the full value proposition of innovative medicines. Specific NPC research objectives include:

  1. Define the optimal role and value of pharmaceuticals in the current and evolving payment and delivery models.
  2. Provide evidence on the optimal use of real-world evidence to demonstrate value.
  3. Provide evidence regarding the appropriate range of therapies needed to achieve better health outcomes for both the individual patient and the population.

Proposal Scope

NPC is currently seeking proposals for both research projects and mini-grants. Scope for each proposal type is defined below.

Research Projects

NPC will consider all proposals that align with any of the aforementioned three research objectives, but particular consideration will be given to innovative research that addresses one of the following policy topics:

  • How have new payment and delivery models impacted patterns of medication use and other types of diagnostic and therapeutic resources? Payment and delivery models of particular interest include accountable care organizations, consumer-directed health plans, and patient-centered medical homes. What are the implications for patients of these new delivery models? Preference will be given to approaches that incorporate a large sample that is generalizable to the overall commercial insurance population.
  • Substantial evidence that unnecessary or cost ineffective care persists. How might the health care system reallocate resources from low- to high-value care in ways that makes high-value care more readily available to patients?
  • How and when has real-world evidence (RWE) been used in coverage and medical decisions? How did it improve the treatment decision or certainty of the decision?
  • What research or tools are needed to facilitate the adoption of high-quality RWE in patient, provider, payer, and policy decision-making?
  • What are the barriers and facilitators to greater access, use and communication of RWE?

While budget and timeframe are project specific, shorter-term projects between $50,000-150,000 with timeframes <12 months will be given higher priority in review, although higher-cost and longer-term projects will be considered. NPC research projects typically have an indirect cost cap of 25%. Pass-through costs (e.g., data acquisition costs, roundtable participant honorarium, travel) are not subject to indirect costs. 


Mini-grants are not of the same size, scope or magnitude as research projects, but are intended to identify best practices to implement or facilitate the translation of good practices into regular and daily practice. NPC will consider mini-grant proposals that identify best practices in support of its research objectives. Examples could include, but are not limited to:  

  • Describe how heterogeneity of treatment effect has impacted decision-making within a network of patients, health center, health system, plan ($5,000 each for a 2-3 page case study).
  • Describe how RWE has impacted decision-making within a network of patients, health center, health system, plan ($5,000 each for a 2-3 page case study).
  • Pilot existing tools and materials to integrate RWE and/or RWE evaluation and interpretation tools into daily practice.

Budgets for mini-grant proposals should not exceed $25,000 and project timeframe should be less than three months.

Submission Guidelines

Submissions will be evaluated based upon a combination of factors, including: the potential impact of the research; availability of data and content; project duration; probability of technical success; cost; and to what extent the research is important to key audiences. Submissions should be sent to Sue Grimes, Administrative Assistant at NPC, and should conform to the proposal template. Proposals should be no more than five pages with the possibility to expand and revise after initial review. Proposals must be submitted no later than 5:00 pm ET on January 30, 2015. NPC will follow-up with all research proposals and mini-grant submissions within eight weeks of the submission deadline. To access past NPC-funded research, please visit If you have any questions, please contact Sue Grimes ( Thank you for your interest and participation.