CER Daily Newsfeed

The Comparative Effectiveness Research Daily Newsfeed®, known for short as the CER Daily Newsfeed®, offers the latest news, research and related information on comparative effectiveness research, real-world data and evidence, value assessment and other important health care topics. 

News from Thursday, September 4, 2025

Articles

Real-World Data Shows Novo Nordisk’s Semaglutide Outperforms Eli Lilly’s Tirzepatide on Cardiovascular Outcomes

(9/4, Katie McCool, The Evidence Base) reports “...Novo Nordisk has reported that Wegovy reduced the risk of heart attack, stroke, or death by 57% compared with tirzepatide in patients with obesity and cardiovascular disease, based on findings from the STEER real-world study. The analysis examined health insurance claims from more than 21,000 US patients in the Komodo Research database who began treatment with either drug from May 2022. After propensity score matching, 10,625 people were included in each group, all aged 45 years or older with overweight or obesity and established cardiovascular disease, but no diabetes.” Full

PhRMA Launches Ad Campaign Urging Congress to Address '340B Medicine Mark-Ups'

(9/3, Dave Muoio, Fierce Healthcare) reports “...The Pharmaceutical Research and Manufacturers of America's (PhRMA's) campaign, called ‘Meet Mark,’ targets the Washington, D.C., market with a combination of videos and other materials running on television, digital and social media platforms. The seven-figure campaign is set to run through the end of the year, the group told Fierce Healthcare. ‘When hospitals have free rein to mark up medicines, everyone pays the price,’ PhRMA wrote in a release outlining the campaign. ‘It is time to stop tax-exempt hospitals from rampantly abusing the program and ensure that the program benefits low-income patients by lowering their medicine costs.’” Full

Australian Govt To Start HTA System Overhaul – One Year After Major Review

(9/4, Eliza Slawther, Pink Sheet) reports “...The Australian government says it is taking ‘immediate actions’ to overhaul its health technology assessment system. This will include updating guidelines around using the lowest cost comparator drug in HTAs, a practice that industry has long opposed.” Subscription Required

Kuwait Advances Evidence-Based Healthcare with New HTA Roadmap

(9/4, Arab Times) reports “Kuwait’s Ministry of Health on Wednesday held a workshop title ‘Drawing a Roadmap to Activate the Health Technology Assessment (HTA) System’ under the patronage and attendance of Minister of Health Dr. Ahmad Al-Awadhi, with participation from ministry leaders, academic partners, and international organizations.” Full

Press Releases

New Tool Detects Problematic Trials Before They Distort Evidence

(9/4, Mia Parkinson, Cochrane News) reports “...The INSPECT-SR tool (INveStigating ProblEmatic Clinical Trials in Systematic Reviews) was created by an international group of researchers to address the risks posed by untrustworthy randomized controlled trials (RCTs)...INSPECT-SR guides reviewers through 21 structured checks across four domains: post-publication notices; study conduct, governance and transparency; text and figures; study results.” Full

Journals

Literature Analysis and Implication of Biologic Therapy for Children with Non-Systemic Juvenile Idiopathic Arthritis in Real-World Settings

Albert Fung, et al.

August 31, 2025, Intractable & Rare Diseases Research

PubMed

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies

Chao Xie, et al.

September 4, 2025, Hypertension

PubMed

Rationale and Design of the Comparative Effectiveness of ICD Versus Non-ICD Therapy in Contemporary Heart Failure Patients at a Low Risk for Arrhythmic Death (CONTEMP-ICD) Trial

Ilan Goldenberg MD, et al.

September 4, 2025, American Heart Journal

American Heart Journal