News from Tuesday, September 23, 2025
Articles
UC Davis Health to Co-Lead $16 Million Study Examining AI’s Role in Reading Mammograms
(9/23, Stephanie Winn, UC Davis Health) reports “...The study, known as the PRISM trial (Pragmatic Randomized Trial of Artificial Intelligence for Screening Mammography), is supported by a $16 million award from the Patient-Centered Outcomes Research Institute (PCORI). The study will involve hundreds of thousands of mammograms interpreted at academic medical centers and breast imaging facilities in California, Florida, Massachusetts, Washington and Wisconsin.” Full
Strengthening Patient Engagement with Plain Language Summaries in HTA
(9/23, The Evidence Base) reports “...[Jose Diaz, Senior Director, Global Health Systems Economics & Value of Innovation, Bristol-Myers Squibb:] The Regulation of HTA in the European Union (EU-HTAR) represents a major opportunity to embed patient involvement more consistently across EU, particularly in the context of joint clinical assessments (JCAs). EU-HTAR requires that patients are involved throughout the JCA process, and this makes their participation both a formal requirement and an essential step towards legitimacy...PLS can serve as a cornerstone of this process.” Full
Potential End of ACO REACH Brings ‘Question Mark’ to Value-Based Care
(9/22, Caroline Catherman, Healthcare Brew) reports “...If ACO REACH ends as planned, participating ACOs could try switching to the MSSP, which in 2025 has 476 ACOs with 655,725 healthcare providers and organizations providing care to 11.2+ million...Switching from ACO REACH to the MSSP would likely still be ‘destabilizing’ to participating healthcare systems and physician practices, Bartley Bryt, chief medical officer of Privia Health, a physician support company that manages nine ACOs known collectively as the Privia Quality Network, told us.” Full
Press Releases
ISPOR Launches New Content on Whole Health
(9/23, ISPOR Press Release) “ISPOR—The Professional Society for Health Economics and Outcomes Research (HEOR) announced that it has launched new website content on whole health, a topic of increasing importance as health systems across the globe grapple with providing the best possible healthcare to patients within constrained budgets...‘ISPOR views whole health as a key topic to advance our vision,’ stated ISPOR’s CEO Rob Abbott. ‘We recognize that the field of HEOR can make a significant impact in informing and moving whole health forward. As the leading professional society in the field of HEOR, we are committed to supporting methods, guidance, and research that include the concept of whole health.’” Full
GAO Appoints PCORI Board of Governors Chairperson and Vice Chairperson
(9/23, PCORI Press Release) “The Comptroller General of the United States, Gene L. Dodaro, who serves as the head of the U.S. Government Accountability Office (GAO), announced the appointment of Russell M. Howerton, M.D., FACS, as the Chairperson of the Patient-Centered Outcomes Research Institute’s (PCORI) Board of Governors, and of Jennifer DeVoe, M.D., MPhil, MCR, DPhil, FAAFP, as the Vice Chairperson through September 2028.” Full
ScreenPoint Medical's Transpara® Breast AI Selected for $16M PRISM Randomized Controlled Trial in USA
(9/23, ScreenPoint Medical Press Release) “ScreenPoint Medical today announced that its Transpara® breast imaging AI solution has been selected as the technology of choice for the PRISM (Pragmatic Randomized Trial of Artificial Intelligence for Screening Mammography) Trial, a landmark randomized controlled trial funded by the Patient-Centered Outcomes Research Institute (PCORI). Fueled by a $16 million award, this is the first large-scale trial in the United States to rigorously evaluate the role of artificial intelligence (AI) in breast cancer screening.” Full
Anova Launches Global Clinical Registry to Accelerate Research and Access to Promising New Treatments
(9/23, Anova Press Release) “...The 21 CFR Part 11 compliant AnovaOS® global clinical registry provides a rich source of real-world evidence about research sites and patients, administrative efficiency in the conduct of research, a tool for post-market surveillance, and information to support data-driven study design, with the effect of faster go-to-market timelines for sponsors.” Full
Journals
Comparative Efficacy and Safety of Left Atrial Appendage Occlusion Versus Direct Oral Anticoagulants in Atrial Fibrillation: A Systematic Review and Meta-Analysis
Manish Juneja, et al.
September 22, 2025, medRxiv