News from Thursday, October 30, 2025
Articles
Video: The Power of Patient Engagement in Insurance, Decision-Making: Kimberly Westrich, MA
(10/30, Pearl Steinzor, The American Journal of Managed Care) “...By collaborating with patients from the very start and respecting their unique perspectives, decision-makers can create a health care environment that prioritizes real-world needs and delivers better results for everyone, says Kimberly Westrich, MA, chief strategy officer, National Pharmaceutical Council. Using an airport acronym, ‘IAD-EVE,’ Westrich shares how good patient engagement includes interaction at all stages of the decision-making process in order to bring patient experiences, values, and expertise to the forefront of health care.” View Video
Real-World Data Key to Optimizing CAR T-Cell Therapy Delivery, Outcomes
(10/29, Brooke McCormick, The American Journal of Managed Care) reports “...From a payer perspective, [Audaire Health’s Andy Berg, PharmD] emphasized that real-world data on CAR T-cell therapies can help address the challenges highlighted by his fellow panelists, arguing that better data leads to improved decisions and outcomes. At the patient level, he is particularly interested in remission rates, durability of response, and treatment outcomes. At the provider level, he focuses on network performance, differences between high- and low-performing sites, and value optimization to support contracting and network design.” Full
Turning Real-World Data into Actionable Drug Development Insights With AI
(10/30, Christopher Cole, PharmTech) reports “...Gustavo Ferrer, MD, CEO of Dr. Ferrer BioPharma and Moxie Health Group, discusses how artificial intelligence is rapidly reshaping how drug development and pharmaceutical manufacturing operate, compressing timelines, reducing costs, and enabling unprecedented real-world data integration. He explores how platforms like Moxie-Link—an AI-powered, Fast Healthcare Interoperability Resources (FHIR)-compliant clinical and research platform—are turning every clinical encounter into actionable intelligence, all while navigating the remaining barriers to wider AI adoption and maximizing innovation through cross-disciplinary collaboration.” Full
The 340B Drug Pricing Program As A Capped Safety-Net Grant
(10/30, Anthony M. DiGiorgio, Deborah Williams, Health Affairs Forefront) comments “...The current financial arbitrage model of 340B is fundamentally flawed. It acts as an inefficient, poorly targeted revenue stream for large hospital systems. Converting this program to a capped safety-net grant solves many problems including the program’s complexity and adverse effects on affordability, while ensuring funds follow low-income patients. Policy makers should prioritize this reform to promote competition and reward institutions which reliably provide access to low-income patients.” Full
Conversations We’re Expecting to Hear at ISPOR Europe 2025: How Can Health Economics Take a Whole Health Perspective?
(10/30, Joanne Walker, The Evidence Base) reports “...Can we have it ‘whole’? Barriers and opportunities for embracing a whole health perspective in HEOR...Building on earlier discussions of whole health, this session will move from concept to application by examining how broadening the scope of economic evaluation can reshape value assessment and policymaking. Using a case study on the societal return on investment of vaccines, panelists will demonstrate how adopting wider perspectives, such as cost-benefit or social decision-making analyses, changes both outcomes and interpretations of value.” Full
Press Releases
Institute for Clinical and Economic Review Publishes Final Evidence Report on Treatment for Non-Cystic Fibrosis Bronchiectasis
(10/30, ICER Press Release) “The Institute for Clinical and Economic Review (ICER) today released a Final Evidence Report assessing the comparative clinical effectiveness and value of brensocatib (Brinsupri™, Insmed Incorporated) for the treatment of non-cystic fibrosis bronchiectasis (NCFB).” Full
NICE’s Backing of the Prostate Cancer Drug Abiraterone Could Help Thousands and Save the NHS Millions
(10/30, NICE Press Release) “Today we’ve published final draft guidance recommending abiraterone and its generic variants in combination with androgen deprivation therapy and prednisolone or prednisone as an option for adults with newly diagnosed high-risk hormone-sensitive metastatic prostate cancer. The decision marks a significant shift from our 2021 guidance, which could not recommend abiraterone because, at the time, it did not represent value for money for the NHS.” Full
Journals
Moderate-High Efficacy Disease-Modifying Therapies Reduce Relapse Risk in Late-Onset Multiple Sclerosis
Yi Chao Foong, et al.
October 29, 2025, Journal of Neurology, Neurosurgery and Psychiatry
Comparative Effectiveness of Dorsal Root Ganglion and Spinal Cord Stimulation in Chemotherapy-Induced Peripheral Neuropathy: A Single-Center Retrospective Case Series
Gregory Blazek, et al.
October 30, 2025, Neuromodulation
Proton Beam vs Intensity-Modulated Radiotherapy in Olfactory Neuroblastoma
Anthony Tang, et al.
October 30, 2025, JAMA Otolaryngology
Letter in Reply – Quality in Qualitative Evidence: New Best Practice Principles from NICE’s Real-World Evidence Framework
Vandana Ayyar Gupta, et al.
October 30, 2025, Journal of Comparative Effectiveness Research
Journal of Comparative Effectiveness Research
Letter to the Editor – Qualitative Evidence Submitted by Patients to NICE: Need for More Quality or Unrealistic and Unfair Requirements?
Rocco Falchetto, Jasmin Barman-Aksözen
October 30, 2025, Journal of Comparative Effectiveness Research
Journal of Comparative Effectiveness Research
Estimating the Willingness-to-Pay per Quality-Adjusted Life Year to aid Health Technology Assessment in India
Yashika Chugh, PhD, et al.
October 30, 2025, Value in Health