News from Wednesday, December 10, 2025
Articles
Ketamine Not a Better Anesthetic for Intubation of Critically Ill Patients
(12/9, Crystal Phend, Medpage Today) reports “For tracheal intubation anesthesia in critically ill patients, ketamine didn't improve survival compared with etomidate, a pragmatic clinical trial showed...Large observational studies had supported lower mortality risk in this setting with ketamine compared with etomidate, although trials were inconclusive.” Full
Press Releases
Sedative Choice Could Improve Outcomes for Breathing Tube Patients
(12/10, Vanderbilt University Medical Center Press Release) “Doctors treating seriously ill patients in an emergency setting may want to give the sedative etomidate, rather than ketamine, while placing a breathing tube, according to a randomized trial published in the New England Journal of Medicine...‘Studies like RSI are critically important to understand the treatments that patients are already receiving and to ensure that patients receive the treatments that will result in the best outcomes,’ [lead author Jonathan Casey, MD] said.” Full
Journals
Comparative Effectiveness and Safety of Systemic Therapies for Treatment-Naïve, PD-L1 Expression< 1% Advanced NSCLC: A Systematic Review and Network Meta-Analysis
Mengyun Zhou, et al.
November 30, 2025, Translational Lung Cancer Research
Alectinib Versus Crizotinib as the First-Line Treatment in Patients with Advanced ALK-Positive Non-Small Cell Lung Cancer: A Chinese Real-World Cohort Study
Haoran Zhang, et al.
November 30, 2025, Translational Lung Cancer Research
Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults
Jonathan D. Casey, M.D., et al.
December 9, 2025, The New England Journal of Medicine
Osimertinib Versus First-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Metastatic EGFR-Mutant Non-Small Cell Lung Cancer: A Target Trial Emulation Study of Real-World Survival and Safety Outcomes
Ren-Hua Ye, et al.
December 9, 2025, JCO Oncology Practice
Efficacy and Safety of Treatments for Metastatic Castration-Sensitive Prostate Cancer: A Comprehensive Network Meta-Analysis Including Final ARANOTE Data
Neal Shore, et al.
December 9, 2025, Prostate Cancer and Prostatic Diseases
Reports
How will a Rebate Model Impact Cash Flow for Price Negotiated Drugs in Medicare Part D?
December 9, 2025