News from Friday, April 24, 2026
Articles
The 340B Drug Pricing Program Is A Hidden Tax Expenditure
(4/24, Ike Brannon, Anthony T. Lo Sasso, Health Affairs Forefront) comments “...The rapid growth of 340B discounts directly reduces the taxable revenue of pharmaceutical manufacturers. As the volume of discounted sales increases, manufacturers’ profits decline, lowering their federal tax liabilities. These losses are not offset by increased access to care; instead, they largely accrue to nonprofit, tax-exempt hospitals in the form of higher margins...In effect, 340B functions as a mandated transfer from taxable firms to tax-exempt entities, precisely the kind of fiscal impact that tax-expenditure accounting is meant to capture.” Full
Why Some Providers Are Steering Clear of CMS’ ACO LEAD Model
(4/24, Diane Eastabrook, Modern Healthcare) reports “...A narrow application window and a requirement that providers meet certain patient enrollment minimums are among the reasons providers cite for postponing or abandoning plans to take part in the Long-term Enhanced Accountable Care Organization Design model known as LEAD.” Subscription Required
Unleashing The Full Potential Of MSSP To Drive Greater ACO Participation And Savings
(4/24, Sean Cavanaugh,Travis Broome, Farzad Mostashari, Health Affairs Forefront) comments “...CMS should hold primary care physicians in MIPS to the same cost standard as an ACO, creating something like an ‘ACO Lite.’ This would increase the validity of the MIPS cost measure...Practices should be paid a one-time ‘site-neutral’ flat fee per beneficiary based on the number of Medicare fee-for-service beneficiaries newly assigned to them in each performance year. CMS should run a beneficiary assignment at the beginning of each performance year and make bonus payments quarterly based on this assignment.” Full
Press Releases
GLP-1–Based Drug Tirzepatide Reduces Heart Risk in High-Risk Patients
(4/23, Society for Cardiovascular Angiography and Interventions Press Release) “...‘This study provides real-world evidence comparing two commonly used diabetes medications in a high-risk population,’ said Revati Varma, internal medicine resident at Cook County Hospital in Chicago. ‘Tirzepatide consistently reduced major cardiovascular events and mortality across multiple time points, which clinicians should actively consider when selecting therapies.’” Full
Johnson & Johnson Launches Landmark Head-to-Head Pulsed Field Ablation Trial in Persistent Atrial Fibrillation
(4/24, Johnson & Johnson Press Release) “...Up to 466 participants across 50 sites will be randomly assigned to receive treatment with either VARIPULSE Pro Platform -the next-generation pulse sequence PFA- or the control FARAPULSE PFA platform1 in patients with persistent atrial fibrillation (AFib). VARIPULSE Pro received CE mark in March, and is not yet approved in the U.S. The study’s primary endpoints include safety, evaluated by the occurrence of primary adverse events, and effectiveness, defined by freedom from arrhythmia recurrences during the evaluation period of 60 days after the procedure.” Full
Journals
Association of Intravenous Versus Oral Iron Therapy With Clinical Outcomes in Patients With Advanced CKD
Adedamola M Adeboye, et al.
March 12, 2026, Kidney Medicine
Comparative Effectiveness and Safety of Phosphorus-Lowering Drugs for CKD 3-5 Stages
Wenping Hou, et al.
March 13, 2026, Kidney Medicine
Differential Outcomes with Empagliflozin and Dapagliflozin in Heart Failure with Mildly Reduced Ejection Fraction with and without Diabetes Mellitus
Ibrahim Mortada MD MS, et al.
April 23, 2026, The American Journal of Cardiology
The American Journal of Cardiology
Maximizing the Impact of Real-World Evidence on Cancer Treatment: What Do We Need to Achieve It?
Begoña Bermejo, et al.
April 24, 2026, Journal of Comparative Effectiveness Research