News from Monday, April 27, 2026
Articles
Value Viewpoint: April 24, 2026
(4/24, Kimberly Westrich, LinkedIn) comments “...New research published in Health Economics Review examines why conventional cost-effectiveness analysis can be a poor fit for drugs treating severe rare diseases...Several HTA bodies have added special pathways, higher thresholds, contextual factors, or broader value elements to better address rare diseases, but this study finds that those changes are inconsistent and often leave the core CEA framework intact. Proposed alternatives such as equity weighting, societal willingness-to-pay, MCDA, disease-specific outcomes, and broader value frameworks could better reflect holistic value, but would require clearer standards and closer collaboration among payers, manufacturers, clinicians, and patient groups.” Full
Moving From Aspirational to Operational Engagement of Patients in Healthcare Decisions
(March/April 2026, Rob Abbott, Value & Outcomes Spotlight) comments “...Traditionally, health economists have defined value based on clinical effectiveness and cost-effectiveness, as reflected in the oft-cited (and sometimes maligned) QALY. When patient experiences are incorporated into notions of value, the concept becomes broader, multidimensional, and more patient-centric. Suddenly, we lift our gaze from a singular focus on outcomes such as survival, disease progression, and clinical biomarkers to consider outcomes that matter in daily life, such as the ability to work or attend school, independence in daily activities, emotional well-being, and social participation—the simple, regular things that shape an individual’s life.” Full
A New Medicare Program That Uses AI for Prior Authorizations Is Hurting Patients and Delaying Care
(4/27, Jessica Hall, MarketWatch) reports “...The program - known as the Wasteful and Inappropriate Service Reduction (WISeR) model - requires additional approvals for more than a dozen medical procedures...‘Procedures that were typically completed within two weeks prior to WISeR now take four to eight weeks. That frequently forces patients to reschedule care multiple times, prolonging pain and allowing underlying conditions to worsen,’ [U.S. Sen. Maria Cantwell] said in the letter...‘This model incentivizes WISeR contractors to weaponize AI-driven medical determinations not for the sake of efficiency, as it could be used, but for the opportunity to maximize profitability,’ Cantwell said in the report.” Full
Journals
Consideration of the Limitations of Cost-Effectiveness Analysis for Severe-Rare Disease Drugs and Potential Solutions: A Structured Literature Review
Jia Pan, et al.
April 18, 2026, Health Economics Review
Comparative Effectiveness of Azithromycin versus Erythromycin for Latency Prolongation in Preterm Prelabor Rupture of Membranes < 34 Weeks of Gestation
Saifon Chawanpaiboon, Julaporn Pooliam
April 21, 2026, International Journal of Women’s Health
Differential Outcomes with Empagliflozin and Dapagliflozin in Heart Failure with Mildly Reduced Ejection Fraction with and without Diabetes Mellitus
Ibrahim Mortada, et al.
April 23, 2026, The American Journal of Cardiology
Rationing by Assumption: De-implementation of Spinal Injections Requires Rigorous Comparative Evidence
Robert W Hurley, et al.
April 23, 2026, The Journal of Pain
Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4-IgG-Positive NMOSD
Jie Lin, et al.
April 24, 2026, Annals of Clinical and Translational Neurology
Outcomes of Drug-Coated Balloon Versus Drug-Eluting Stent for In-Stent Restenosis and De-Novo Lesions: A Meta-Analysis of Randomized Controlled Trials
Arman Soltani Moghadam, et al.
April 24, 2026, Health Science Reports
Editorial Commentary: When Efficacy is Similar, Risk Should Decide: Why Ketorolac Deserves Priority Over Corticosteroids For Hip Injections
Lyall J Ashberg
April 24, 2026, Arthroscopy
Bayesian Methods in Nephrology: Applications in Adaptive Trials, Dynamic Risk Prediction, Pharmacokinetics, and Causal Inference
Concetto Sessa, et al.
April 25, 2026, Nephrology, Dialysis, Transplantation
Using Regression Discontinuity in Time to Strengthen Real-World Evidence: A Case Study in Lung Cancer
Nai-Chia Chen, et al.
April 26, 2026, Medical Decision Making
Semaglutide and Tirzepatide for Obesity: A Summary from the Institute for Clinical and Economic Review's New England Comparative Effectiveness Public Advisory Council: A Summary from the Institute for Clinical and Economic Review’s New England Comparative Effectiveness Public Advisory Council
Foluso Agboola, MBBS, MPH, et al.
April 27, 2026, Journal of Managed Care & Specialty Pharmacy
Reports
Fact Sheet: A Cost of Caps: Risks to Patient Access Amid PDAB Upper Payment Limit Implementation
April 21, 2026
Events
Comparative Clinical Effectiveness Research Advisory Panel Spring 2026 Meeting
May 1, 2026
10:00AM - 3:30PM ET