CER Daily Newsfeed

The Comparative Effectiveness Research Daily Newsfeed®, known for short as the CER Daily Newsfeed®, offers the latest news, research and related information on comparative effectiveness research, real-world data and evidence, value assessment and other important health care topics. 

News from Tuesday, May 5, 2026

Articles

Washington DC's 500 Most Influential People of 2026

(5/5, Jacob Raim, Washingtonian) comments “...John M. O'Brien, National Pharmaceutical Council, President and CEO. O'Brien's research convinced advocates and lawmakers that the Inflation Reduction Act's price controls were stifling orphan-drug development—fueling the only bipartisan fix to its health provisions included in last year's reconciliation bill.” Full

 

How the Waste in Healthcare Drives the U.S. Debt

(5/5, James Weinstein, Los Angeles Times) comments “...The pattern is clear: High-value care is underused, supply drives overuse and preference-sensitive decisions proceed without informed consent — failures that demand better tools to link evidence, capture patient preferences and document decisions at scale. The fixes are clear, too: organized delivery, shared decision-making, comparative-effectiveness research and payment tied to outcomes.” Subscription Required

 

Most-Favored-Nation Drug Pricing to Save U.S. $529 Billion Over 10 Years, Report Suggests

(5/5, Elias Schisgall, Dow Jones) reports “The Trump administration's efforts to get drug makers to cut prices on new drugs for U.S. patients are expected to generate around $529 billion in domestic savings over the next decade, according to an analysis by the Council of Economic Advisers...‘By tying U.S. drug prices to international prices, prospective MFN will lower U.S. prices and put upward pressure on prices paid in other wealthy nations,’ the Council of Economic Advisers wrote in its report.” Full

 

Trump's Drugmaker Deals May Save Economy $529B over 10 Years, White House Says

(5/5, Josh Boak, Associated Press) reports “...The scope of the savings claimed by the Trump administration are likely to intensify the scrutiny by Democrats, who counter that any price reductions would be offset by higher costs for prescription drugs not covered by the ‘most favored nation’ framework. One of their main critiques is that pharmaceutical companies have increased their profit margins while working with the administration.” Full

 

Video: Asembia ASX26: How Payers are Embracing Value-Based Care Models for Cell & Gene Therapies

(5/5, Mike Hollan, Will Shrank, PharmExec) “While advances in cell & gene therapy continue to show promise for creating new treatments, this sector of the industry still faces a major hurdle: the high costs. Whether it’s on the R&D side or delivering and administering the treatment to the patients, cell& gene therapies are expensive. Pharmaceutical Executive spoke with Aradigm Health CEO Will Shrank at the Asembia ASX26 Summit in Las Vegas. During the conversation, he explained the issues the payers face with cell & gene therapies, along with the strategies that the industry is using to move forward with these treatments.” View Video

 

Ojemda: Publication Of First Ever EU Joint Clinical Assessment Report Is Imminent

(5/5, Francesca Bruce, Pink Sheet) reports “...Ipsen’s Ojemda (tovorafenib) is the subject of the first ever EU-level joint clinical assessment report to be finalized. The report was endorsed just days after the product gained conditional marketing authorization.” Subscription Required

Press Releases

Verana Health Transforms Site Selection and Patient Enrollment in Clinical Trials

(5/5, Verana Health Press Release) “...‘Data-driven trials informed by RWD start with a stronger foundation, potentially avoiding mismatched enrollment, unexpected side effects and costly delays that plague traditional trials,’ said Sujay Jadhav, CEO of Verana Health. ‘In an era of complex research and heightened competition for limited trial sites and study cohorts, the access to timely, accurate real-world information on patients can influence a critical difference between a study that becomes mired in problems and one that meets success.’” Full

Journals

Comparative Effects of Non-Pharmacological Interventions on Anxiety, Depression and Quality of Life in Individuals with Substance Use Disorders: A Systematic Review and Network Meta-Analysis

Haoran Luo, et al.

May 2, 2026, Journal of Affective Disorders

PubMed

 

Therapeutic Opportunities for Ferroptosis In Lipopolysaccharides- Induced Acute Kidney Injury; Liproxstatin-1 Versus N- Acetyl Cysteine

Heba F Ibrahim, et al.

May 2, 2026, European Journal of Pharmacology

PubMed

 

Extending Inferences from a Randomized Trial to Trial-Eligible and Treatment-Candidate Target Populations: Examples of Generalizability and Transportability

Young, Jessica C., et al.

May 4, 2026, Epidemiology

Epidemiology

 

Pharmacological Treatment for Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis of 71 Randomized Controlled Trial

Xiaowei Liu, et al.

May 4, 2026, Diabetes, Obesity & Metabolism

PubMed

 

Outcomes Associated With Hospital at Home vs Traditional Inpatient Stay

J. Priyanka Vakkalanka, PhD; Tracy L. Young, MS; Gabriel Bianchi, MD, et al.

May 5, 2026, JAMA Network Open

JAMA Network Open

 

Evidence Synthesis via Indirect Treatment Comparisons in the European Framework of Joint Clinical Assessment

Alberto de la Cuadra-Grande, et al.

May 5, 2026, Epidemiologia

Epidemiologia

 

R WE Ready for Reimbursement? A Round-Up of Developments in Real-World Evidence Relating to Health Technology Assessment: Part 26

Paul Arora and Sreeram V Ramagopalan

May 5, 2026, Journal of Comparative Effectiveness Research

Journal of Comparative Effectiveness Research

Reports

Savings from Most-Favored-Nation Drug Pricing Policy

May 5, 2026

The Council of Economic Advisers