News from Monday, December 2, 2024
Articles
Video: From Data to Dialogue: Transforming Oncology With Real-World Evidence
(11/29, Skylar Jeremias, The American Journal of Managed Care) “Sandra Cuellar, PharmD, from the University of Illinois Chicago, highlights the critical role of real-world data in shaping reimbursement models for oncology therapies and emphasizes the growing importance of patient-centered care through shared decision-making, precision medicine, and patient-reported outcomes.” View Video
Gene Therapy Explosion Forces Employer Coverage to Get Creative
(12/2, Lauren Clason, Bloomberg Law) reports “...Several manufacturers offer pricing flexibility through rebates tied to the therapy’s results or a series of payments that can be made over time. These deals are typically struck with insurance companies or pharmacy benefit managers that offer employers supplemental coverage. The arrangements help when there’s ‘true uncertainty’ about a drug, but often function as just another rebate off the list price, said Anna Kaltenboeck, who leads ATI Advisory’s Prescription Drug Reimbursement Practice. Critics allege the current rebate system incentivizes higher list prices instead of driving them down.” Full
Big Pharma Pushes Trump Team to Ease Medicare Drug Price Negotiation Rules
(11/27, Michael Erman, Patrick Wingrove, Maggie Fick, Reuters) reports “...One source at a big pharmaceutical company said the company had both phone calls and in-person meetings with members of the Trump transition team to discuss possible changes to the IRA. The company hopes a Republican Congress and the Trump administration would remove the distinction in how the easier to produce drugs are treated. ‘They have been receptive,’ the source said, declining to say whom the company had spoken to on the transition team.” Full
Press Releases
Canada’s Drug Agency Launches Consultation on Methods Guide
(11/28, Canada’s Drug Agency Press Release) “...Canada’s Drug Agency is launching a consultation on our first-ever methods guide. The development of the guide and our open consultation are both part of our ambition to increase the transparency of our processes and provide a better understanding of our work. This document describes the methods involved in conducting a health technology assessment (HTA) and focuses on the appraisal of the clinical evidence for a drug as submitted by a sponsor to our Drug Reimbursement Review program.” Full
IQWiG Evaluates Smoking Cessation Drugs for Severe Tobacco Dependence Treatment
(11/27, IQWiG Press Release) “...IQWiG has now published its final benefit assessment of bupropion, cytisine, nicotine and varenicline for smoking cessation, also in combination with each other, compared with no drug therapy. According to the findings, there is proof of greater benefit for treatment with nicotine and varenicline...” Full
Journals
Biosimilar Monoclonal Antibodies for Cancer Treatment in Adults
Tais F Galvao, et al.
November 28, 2024, The Cochrane Database of Systematic Reviews
Comparative Effectiveness of Buprenorphine/Naloxone and Methadone on Methamphetamine/Amphetamine Use Among People with Opioid Use Disorder in Canada
Jenna Langlois, et al.
November 29, 2024, Substance Use & Addiction Journal
Comparative Effectiveness of Three Common SARS-COV-2 Vaccines: A Network Meta-Analysis of Randomized Trials
A A Syed, et al.
November 29, 2024, Semergen
Imetelstat for Anemia in Lower-Risk Myelodysplastic Syndromes: A Summary from the Institute for Clinical and Economic Review’s California Technology Assessment Forum
Shahariar Mohammed Fahim, PhD, Jeffrey A. Tice, MD, Linda Luu, MSc, Josh J. Carlson, MPH, PhD, Marina Richardson, MSc, PhD, Belen Herce-Hagiwara, BA, Ronald Dickerson, MPH, M.Econ., and Daniel A. Ollendorf, PhD, MPH
November 29, 2024, Journal of Managed Care & Specialty Pharmacy
Assessing the Value of New Antimicrobials: Evaluations of Cefiderocol and Ceftazidime-Avibactam to Inform Delinked Payments by the NHS in England
Beth Woods, et al.
November 30, 2024, Applied Health Economics and Health Policy
Comparative Outcomes of Warfarin vs. Direct Oral Anticoagulants (DOACs) in Anticoagulant-Related Gastrointestinal Bleeding: A Single-Center Study
Naqeeb Ullah, et al.
December 1, 2024, Cureus
Rota-Tripsy or Step-Up-Approach Rotational Atherectomy for Severe Coronary Artery Calcification Treatment: A Comparative Effectiveness Study
Fengwen Cui, et al.
December 2, 2024, Scientific Reports
Drug Prices Negotiated by Medicare vs US Net Prices and Prices in Other Countries
Olivier J. Wouters, PhD; Sean D. Sullivan, BScPharm, PhD; Emma M. Cousin, PharmD; et al
December 2, 2024, JAMA