CER Daily Newsfeed

Exploring Primary Care Treatment Options Through Patient-Centered Comparative Clinical Effectiveness Research

(12/2, The PCORI Blog) comments “...PCORI funds patient-centered comparative clinical effectiveness research (CER) to help answer these questions. By comparing real-world treatment options, these studies generate evidence that supports better-informed decision making for patients, caregivers and the broader healthcare community. Take a closer look at the growing evidence with two examples of PCORI-funded patient-centered CER in primary care.” Full

Overcoming Barriers to Cell and Gene Therapy Adoption with Real-World Evidence

(12/1, The Evidence Base) reports “This Deep Dive examines insights from a recent ISPOR webinar hosted by the PPD Evidera Solutions team at Thermo Fisher Scientific, exploring how real-world data and evidence can address the evidentiary, operational, access and uptake challenges shaping the future of cell and gene therapies...They explored how real-world data (RWD) and real-world evidence (RWE) can be integrated within a comprehensive and holistic regulatory and access strategy to help address the practical hurdles that threaten to inhibit CGT adoption. The discussion unfolded around three core themes: the opportunities that CGTs offer, the challenges in value demonstration, and how RWE can bridge the gaps between innovation, evidence generation, and patient access.” Full

Partnership Makes Performance: Integrating Quality Improvement and Implementation Science to Advance Healthcare

(12/1, Julie A. Bednark, Northwestern Medicine Department of Medical Social Sciences) reports “...For [Kelli Scott, PhD], Assistant Professor in MSS and CDIS and the Director of the Northwestern University Clinical and Translational Sciences (NUCATS) Dissemination and Implementation Science Consult Service, the growing partnership between implementation science and quality improvement at Northwestern Medicine represents a new frontier. With [Patricia D. Franklin, MD, MBA, MPH], Scott is co-leading efforts to bridge these disciplines through the Patient-Centered Outcomes Research Institute (PCORI) Health Systems Implementation Initiative (HSII), a national program that funds health systems to implement evidence-based practices.” Full

CMMI Debuts ACCESS Model to Spur Use of Tech in Chronic Disease Treatment

(12/1, Emma Beavins, Fierce Healthcare) reports “...The Center for Medicare and Medicaid Innovation (CMMI) plans to use outcomes-aligned payments to cover the cost of technology for Medicare providers if a patient with a qualifying chronic condition achieves clinically significant results, like lowering their blood pressure.” Full

UK Raises NICE QALY Thresholds Amid New UK–US Drug Pricing Deal

(12/2, Joanne Walker, The Evidence Base) reports “...NICE said the revised thresholds will allow its committees to reflect contemporary commercial and economic conditions and support recommendations for treatments that deliver substantial health gains but may previously have fallen outside the cost-effectiveness range...The measures are accompanied by plans for NICE to adopt a new value set alongside EQ-5D-5L to generate the health utility values that inform QALY calculations. The new set, to be introduced following peer review and consultation, is expected to influence cost-effectiveness estimates and may improve the cost-effectiveness of medicines on average.” Full