News from Friday, December 5, 2025
Articles
Comparing Ways To Reduce Medicine Use Among Older Adults With Type 2 Diabetes
(12/5, PCORI) comments “‘We've come a long way in terms of diabetes care,’ says Richard Grant, M.D., MPH. ‘But all of it has to be looked at through a different lens as people get older.’ As the principal investigator of the PCORI-funded patient-centered comparative clinical effectiveness research study ‘Comparing Two Ways To Reduce Medicine Use Among Older Patients With Type 2 Diabetes,’ Richard knows this concern is increasingly relevant as the U.S. population ages...PCORI funds patient-centered CER studies to help patients and those who care for them make better-informed decisions in situations like these. ‘There’s no algorithm to decide who needs these medications and who doesn’t,’ Richard explains. ‘There’s so much more to it than just the data available in a patient’s chart.’” Full
Exclusive: Trump Administration Pushes End-of-Term Deadline for 'Most Favored Nation' Promises
(12/4, Anna Brown, Endpoints News) reports “...Large pharma companies that have made ‘most favored nation’ deals with the White House will have until the end of President Donald Trump's current term to fulfill some of their commitments to invest in the US, according to a framework of the agreements reviewed by Endpoints News...According to the document, the government and the companies will agree ‘in good faith’ on the amount of money that needs to be spent ‘to transfer to the US the manufacture of all pharmaceutical products and ingredients’ that are imported and consumed in the US. Products that are exempt from the Commerce Department's ongoing trade investigation won't be included.” Subscription Required
New UK Cost-Effectiveness Thresholds Will Not Mean A Reprieve For Drugs Already Denied Reimbursement
(12/5, Francesca Bruce, Pink Sheet) reports “...Some companies in the UK undergoing a health technology appraisal by the HTA body, NICE, will see reimbursement recommendations for their products paused in the run up to the implementation of higher cost-effectiveness thresholds.” Subscription Required
Journals
Comparative Effectiveness and Pharmacological Fingerprints of Indobufen Versus Rivaroxaban in Patients with Chronic Kidney Disease: A Single-Center, Real-World Study
Lijun Zhang, et al.
November 19, 2025, Frontiers in Pharmacology
Comparative Effectiveness of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors Versus Erythropoiesis-Stimulating Agents on Prognosis in Non-Dialysis Chronic Kidney Disease: A Propensity-Matched Cohort Study
Yi-Chou Hou, et al.
December 2025, Renal Failure
Digital Twins: Unlocking Comparative Evidence That Clinical Research Urgently Needs
Andrej Belancic, et al.
December 4, 2025, British Journal of Clinical Pharmacology
Comparative Effectiveness of Adjuvant Treatment for Hepatocellular Carcinoma with High Risk of Recurrence: A Systematic Review and Network Meta-Analysis
Zha Peng, et al.
December 4, 2025, PLOS One
Comparative Effectiveness of Robotic and Laparoscopic Radical Prostatectomy: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials Featuring Geographic Subgroup Analyses
Wajahat Mirza, et al.
December 5, 2025, Journal of Robotic Surgery
Re-Analyzing Value Assessments in AHA Clinical Practice Guidelines Using Health Years in Total Instead of QALYs
Jihye Han, Pharm.D., M.P.H., Andrea Luviano, M.D., M.P.H., Ankur Pandya, Ph.D.
December 5, 2025, Value in Health
Longitudinal Clinical Trial Enrollment Trends Across 341 US FDA-Approved Drugs and Their Guiding Role in Precision Medicine Strategies
Sophie Zaaijer, Simon C. Groen
December 5, 2025, Communications Medicine
Reports
How Well Has Cost-Effectiveness Predicted Drug Market Success? Evidence of Omitted Value
December 4, 2025