CER Daily Newsfeed

The Comparative Effectiveness Research Daily Newsfeed®, known for short as the CER Daily Newsfeed®, offers the latest news, research and related information on comparative effectiveness research, real-world data and evidence, value assessment and other important health care topics. 

News from Friday, December 5, 2025

Articles

Comparing Ways To Reduce Medicine Use Among Older Adults With Type 2 Diabetes

(12/5, PCORI) comments “‘We've come a long way in terms of diabetes care,’ says Richard Grant, M.D., MPH. ‘But all of it has to be looked at through a different lens as people get older.’ As the principal investigator of the PCORI-funded patient-centered comparative clinical effectiveness research study ‘Comparing Two Ways To Reduce Medicine Use Among Older Patients With Type 2 Diabetes,’ Richard knows this concern is increasingly relevant as the U.S. population ages...PCORI funds patient-centered CER studies to help patients and those who care for them make better-informed decisions in situations like these. ‘There’s no algorithm to decide who needs these medications and who doesn’t,’ Richard explains. ‘There’s so much more to it than just the data available in a patient’s chart.’” Full

Exclusive: Trump Administration Pushes End-of-Term Deadline for 'Most Favored Nation' Promises

(12/4, Anna Brown, Endpoints News) reports “...Large pharma companies that have made ‘most favored nation’ deals with the White House will have until the end of President Donald Trump's current term to fulfill some of their commitments to invest in the US, according to a framework of the agreements reviewed by Endpoints News...According to the document, the government and the companies will agree ‘in good faith’ on the amount of money that needs to be spent ‘to transfer to the US the manufacture of all pharmaceutical products and ingredients’ that are imported and consumed in the US. Products that are exempt from the Commerce Department's ongoing trade investigation won't be included.” Subscription Required

New UK Cost-Effectiveness Thresholds Will Not Mean A Reprieve For Drugs Already Denied Reimbursement

(12/5, Francesca Bruce, Pink Sheet) reports “...Some companies in the UK undergoing a health technology appraisal by the HTA body, NICE, will see reimbursement recommendations for their products paused in the run up to the implementation of higher cost-effectiveness thresholds.” Subscription Required

Journals

Comparative Effectiveness and Pharmacological Fingerprints of Indobufen Versus Rivaroxaban in Patients with Chronic Kidney Disease: A Single-Center, Real-World Study

Lijun Zhang, et al.

November 19, 2025, Frontiers in Pharmacology

PubMed

Comparative Effectiveness of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors Versus Erythropoiesis-Stimulating Agents on Prognosis in Non-Dialysis Chronic Kidney Disease: A Propensity-Matched Cohort Study

Yi-Chou Hou, et al.

December 2025, Renal Failure

PubMed

Digital Twins: Unlocking Comparative Evidence That Clinical Research Urgently Needs

Andrej Belancic, et al.

December 4, 2025, British Journal of Clinical Pharmacology

Wiley

Comparative Effectiveness of Adjuvant Treatment for Hepatocellular Carcinoma with High Risk of Recurrence: A Systematic Review and Network Meta-Analysis

Zha Peng, et al.

December 4, 2025, PLOS One

PubMed

Comparative Effectiveness of Robotic and Laparoscopic Radical Prostatectomy: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials Featuring Geographic Subgroup Analyses

Wajahat Mirza, et al.

December 5, 2025, Journal of Robotic Surgery

PubMed

Re-Analyzing Value Assessments in AHA Clinical Practice Guidelines Using Health Years in Total Instead of QALYs

Jihye Han, Pharm.D., M.P.H., Andrea Luviano, M.D., M.P.H., Ankur Pandya, Ph.D.

December 5, 2025, Value in Health

Value in Health

Longitudinal Clinical Trial Enrollment Trends Across 341 US FDA-Approved Drugs and Their Guiding Role in Precision Medicine Strategies

Sophie Zaaijer, Simon C. Groen

December 5, 2025, Communications Medicine

Communications Medicine

Reports

How Well Has Cost-Effectiveness Predicted Drug Market Success? Evidence of Omitted Value

December 4, 2025

CEVR - Tufts Medical Center