News from Thursday, January 22, 2026
Articles
Comparative Effectiveness of Diabetes Medications Revealed
(1/22, Bioengineer.org) reports “...Among the key findings, the study reveals significant variations in treatment effectiveness across different medications. For instance, some agents were found to lead to more substantial improvements in glycemic control compared to others, indicating a need for personalized medicine in diabetes care. Additionally, the implications of these findings extend beyond just clinical outcomes; they also touch upon quality of life measures which are critical considerations for patients managing chronic conditions.” Full
SGLT2 Inhibitors Linked to Lower Risk of CKD, AKI Than GLP-1 RAs
(1/21, Pearl Steinzor, The American Journal of Managed Care) reports “...‘Notably, the differences in kidney outcomes were consistent across subgroups and most pronounced among individuals without preexisting kidney disease, which underscores a potential for primary prevention,’ wrote the researchers. ‘Importantly, the divergent outcomes of eGFR [estimated glomerular filtration rate] and albuminuria suggest that combined treatment may offer additive benefits, which should be explored in future studies.’” Full
Comparing COPD Treatments: FF/1 UMEC/VI vs. BUD/GLY/FORM
(1/22, Bioengineer.org) reports “...A pivotal study by Wedzicha et al. has sparked a response that delves into the comparative effectiveness of different treatment combinations for patients transitioning from dual therapy to more advanced pharmacological interventions. This discourse not only highlights the evolving landscape of COPD management but also underscores the pressing need for continued research in this domain.” Full
Press Releases
Thousands Living with Lupus Offered Hope from Twice-Yearly Infusion
(1/22, NICE Press Release) “The treatment has been approved for NHS use, offering new hope to the nearly 12,000 people in England living with lupus nephritis. Obinutuzumab (Gazyvaro), a twice-yearly infusion that, combined with daily immunosuppressant tablets, significantly outperforms the usual treatments for the disease.” Full
Journals
Comparative Effectiveness of Bone-Protective Interventions for Aromatase Inhibitors-Induced Bone Loss in Postmenopausal Women with Early Breast Cancer: A Network Meta-Analysis
Yonghui Xu, et al.
January 6, 2026, Frontiers in Oncology
Comparative Effectiveness of Current Glucose-Lowering Medications in Type 2 Diabetes Mellitus: Emulation of a Modified GRADE Trial
Avik Ray MD, MS, et al.
January 21, 2026, Journal of General Internal Medicine
NMA: Network Meta-Analysis Based on Multivariate Meta-Analysis and Meta-Regression Models in R
Hisashi Noma, et al.
January 21, 2026, medRxiv
Response to: Letter to the Editor Regarding “Comparative Effectiveness of FF/1 UMEC/VI and BUD/GLY/FORM in Patients with COPD Stepping Up From Dual Therapy”
Jadwiga A. Wedzicha, et al.
January 22, 2026, Advances in Therapy
Patient-Reported Outcomes and Multiple Sclerosis Therapies
Paola Zaratin, et al.
February 2026, The Lancet Neurology