News from Tuesday, February 24, 2026
Articles
ISPOR’s Laura Pizzi and Mitch Higashi on the 2026–2027 Top 10 HEOR Trends and Their Implications for Evidence and Access
(2/24, The Evidence Base) reports “...[ISPOR’s Dr Laura Pizzi (Chief Science Officer) and Dr Mitch Higashi (Associate Chief Science Officer):] As for value measurement, we continue to see interest from HTA, payers, and patient representatives on expanded value measures. The reality is that HEOR hasn’t done a great job at bringing expanded measures into our assessments; for example, despite there being established measures for productivity and caregiver impacts, those haven’t routinely been included in HEOR assessments for a number of reasons – lack of data, lack of relevance to the stakeholder making the decision, lack of relevance to the intervention being studied.” Full
Drugmakers Lay out Their Legal Arguments Against Trump’s Drug Pricing Experiments
(2/24, John Wilkerson, STAT+) reports “...Initially, the Medicare demonstrations would cover about a quarter of seniors, but they could be extended and applied to all Medicare beneficiaries after the pilot period expires...[PhRMA and BIO] say the demonstrations are unconstitutional for multiple reasons. For one, Congress didn’t pass a law creating the demonstrations, and the demonstrations don’t adhere to the law that allows for them. They also argue that the demonstrations violate the Constitution’s protections for patents by demanding lower prices on patented products before patents have expired.” Subscription Required
UK: Joy as NICE Changes Tack on First NHS vitiligo Treatment
(2/24, Phil Taylor, PharmaPhorum) reports “...Reimbursement authority NICE has said that Incyte's JAK inhibitor cream Opzelura (ruxolitinib) can be used to treat people aged 12 and over with vitiligo affecting the face, where off-label topical treatments, like steroids and immunosuppressants, have not worked or are unsuitable.” Full
Press Releases
New Real-World Data Reinforce Earlier Use of Pluvicto® Before Chemotherapy in Metastatic Castration-Resistant Prostate Cancer
(2/24, Novartis Press Release) “In the real-world, Pluvicto® showed 13.5 months median PFS in chemo-naïve patients with PSMA-positive mCRPC. Real world evidence showed Pluvicto achieved longer PFS when initiated after one ARPI instead of multiple ARPIs.” Full
ISPOR’s “HEOR Explained” and “HEOR News Desk” Win Major Industry Awards
(2/24, ISPOR Press Release) “...We are very pleased to see the HEOR Explained website and videos, along with ISPOR’s HEOR News Desk be recognized with these prestigious industry awards, stated ISPOR CEO Rob Abbott. ‘HEOR insights can make a significant difference in improving the lives of patients and transforming healthcare. This honor is very meaningful and highlights the important work of making the field of HEOR better understood by those who can benefit from it. These initiatives are in service of our vision of a world where healthcare is accessible, effective, efficient, and affordable for all.’” Full
Journals
Handling Incomplete Outcomes and Covariates in Cluster-Randomized Trials: Doubly Robust Estimation, Efficiency Considerations, and Sensitivity Analysis
Bingkai Wang, et al.
January 6, 2026, Biometrics
Broadening the Clinical and Research Implications of Comparative Effectiveness for Early-Stage NSCLC Without Lymph Node Involvement
Weiyi Jiang, et al.
February 2026, International Journal of Surgery
Association of Propofol Vs. Sevoflurane Maintenance Anesthesia with Postoperative Delirium, Cognitive Decline, and Mortality in Older Adults: A Global Comparative-Effectiveness Study
Mingyang Sun, et al.
February 23, 2026, Critical Care
NetMetaEasy: Enabling Rapid and User-friendly Network Meta-Analysis (NMA) for Comparative Effectiveness Research
János Tibor Fekete, et al.
February 23, 2026, British Journal of Pharmacology
Bayesian Indirect Comparison and Cost-Effectiveness of Sacituzumab Govitecan Versus Sacituzumab Tirumotecan in Metastatic Triple-Negative Breast Cancer
Yamin Shu, MSc, et al.
February 24, 2026, Value in Health
Risk of Heart Failure Hospitalization for GLP-1 Receptor Agonists Versus DPP-4 Inhibitors or SGLT-2 Inhibitors in Patients With Type 2 Diabetes: A Target Trial Emulation
Yang Xu, et al.
February 24, 2026, Circulation
Reports
Therapeutic Characteristics of the Proposed Mandatory International Reference Pricing Models
February 19, 2026
National Pharmaceutical Council
U.S. Biopharmaceutical Leadership Amidst Changing Price Regulation
February 19, 2026
National Pharmaceutical Council
How Mandatory International Reference Pricing Uses Prices From Countries That Don't Meet Stated Criteria
February 19, 2026
National Pharmaceutical Council
Data Curation Best Practices and Innovations for Real-World Evidence Generated Using Electronic Health Record-Sourced Data
February 20, 2026