CER Daily Newsfeed

The Comparative Effectiveness Research Daily Newsfeed®, known for short as the CER Daily Newsfeed®, offers the latest news, research and related information on comparative effectiveness research, real-world data and evidence, value assessment and other important health care topics. 

News from Tuesday, September 30, 2025

Articles

Reforming Medicare Quality Measurement

(9/30, Joel White, Joseph Puthumana, Peter Cram, Ge Bai, Health Affairs Forefront) comments “...Quality measures should be refocused toward meaningful health outcomes and patient improvement rather than an excessive box-checking exercise in which physicians—working through algorithms built into electronic health records—are forced to spend inordinate amounts of time on documentation...For example, according to a Commonwealth Fund issue brief, clinicians have referred to value-based payment models as ‘just fee-for-service with this extra layer of reporting and accountability that the system is not structured to support,’ and primary care physicians cited burdensome coding and documentation requirements as primary reasons they have avoided adopting those models.” Full

Real-World Evidence Complements and Contextualizes Randomized Clinical Trial Insights in Colorectal Cancer

(9/30, Ashley Chan, OncLive) reports “...‘[Randomized clinical trials] all seem to be relatively interchangeable at face value. Differences are primarily the toxicities, and efficacy is all very similar in the range, especially when we focus on survival, which is the ultimate end point,’ [Tanios S. Bekaii-Saab, MD] said. ‘Frankly, this is where we take our real-world evidence data and apply that standard to help us in practice. Therefore, there's a role for both [clinical trial data and real-world evidence], and it's essentially a role that allows us to use them complementarily, to inform practice.’” Full

Press Releases

First Randomized Study Comparing Proton and Photon Radiation Therapy for Breast Cancer Finds Both Preserve Quality of Life

(9/29, American Society for Radiation Oncology Press Release) “The first randomized trial to compare photon- and proton-based radiation therapy for breast cancer finds that patients report equally strong health-related quality of life with either treatment. Patients who received proton therapy were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.” Full

Institute for Clinical and Economic Review to Assess Vaccines for COVID-19

(9/29, ICER Press Release) “The Institute for Clinical and Economic Review (ICER) announced today that it will assess the comparative clinical effectiveness and value of Comirnaty® (Pfizer, BioNTech), Spikevax® (Moderna), mNexspike® (Moderna), and Nuvaxovid® (Novavax) for the prevention of COVID-19, including both the short- and long-term effects of the infection. The assessment will be publicly discussed during a meeting of the New England CEPAC in June 2026, where the independent evidence review panel will deliberate and vote on evidence presented in ICER’s report.” Full

Journals

Comparative Effectiveness of Prasugrel versus Ticagrelor in Dialysis-Dependent End Stage Renal Disease Patients Undergoing Percutaneous Coronary Intervention

Usman Ali Akbar, et al.

September 27, 2025, The American Journal of Cardiology

PubMed

Comparing Causal Inference Methods for Point Exposures with Missing Confounders: A Simulation Study

Luke Benz, et al.

September 29, 2025, BMC Medical Research Methodology

BMC Medical Research Methodology

Comparative Effectiveness of Antiviral Treatment on Household Transmission of SARS-CoV-2: A Retrospective Cohort Study Using Administrative Data

Kazuhiko Ikeuchi, et al.

September 29, 2025, BMC Infectious Diseases

PubMed

Comparative Effectiveness of Echinocandins and Liposomal Amphotericin B for Fluconazole-Resistant Candida Parapsilosis Bloodstream Infections

Antonio Vena, et al.

September 30, 2025, Antimicrobial Agents and Chemotherapy

PubMed

Comparative Effectiveness of Carbetocin Versus Oxytocin in Active Management of the Third Stage of Labour for Preventing Atonic Postpartum Haemorrhage: A Study at a Tertiary Care Centre in Central India

Nalini Mishra, et al.

September 30, 2025, Cureus

Cureus