News from Wednesday, October 1, 2025
Articles
2025 PCORI Annual Meeting Will Showcase How PCORnet® Supports Engaged Comparative Clinical Effectiveness Research and Maternal Health Research
(9/30, PCORnet Blog) comments “...Patient engagement is critical to successful CER, but engaging patients in large-scale research requires the resources and workforce development to support their successful involvement. At a breakout session on October 21 at 2:15pm, hear from Lindsay Mayberry, PhD, one of the lead investigators for the Coordinating Center for PCORnet®, and Jeff Ordway, Patient Partner and fellow co-investigator, on how Patient Partners and research staff are using the PCORI-funded PCORnet infrastructure to build teams that are better equipped to participate in patient-centered CER and discover how this collaboration can transform both studies and careers.” Full
Press Releases
New CEVR Study Examines Coverage Policies for Cell and Gene Therapies
(9/30, Center for the Evaluation of Value and Risk in Health Press Release) “A new study from the Center for the Evaluation of Value and Risk in Health (CEVR) at Tufts Medical Center provides new empirical data on how US commercial health insurers cover cell and gene therapies; finding that they frequently impose restrictions on patient access, in some cases beyond what is specified in the therapies’ FDA-approved labeling...‘These findings highlight the tension insurers face when balancing evidence, cost, and patient access,’ said James Chambers, PhD, MPharm, Professor of Medicine at CEVR. ‘While many restrictions mirror trial eligibility criteria, variation across plans can create inequities in access and logistical barriers for patients and providers.’” Full
NICE Expands HealthTech Evaluations for NHS Patients
(10/1, NICE Press Release) “NICE will apply the same rigorous standards to evaluate medical devices, diagnostics and digital tools that currently assess new medicines. The expanded programme addresses longstanding inequalities in technology adoption across different NHS regions. Technologies meeting NICE's standards will receive strong recommendations for NHS-wide implementation, supported by clear guidance on value and effectiveness.” Full
Journals
Indirect Comparison of the Immunogenicity of 15-Valent and 20-Valent Pneumococcal Conjugate Vaccines in Children Using a 2 + 1 Schedule
Shahrul Mt-Isa, et al.
September 30, 2025, Expert Review of Vaccines
Approaches for Estimating COVID-19 Vaccine Effectiveness Using Observational Data in Administrative Databases: A Systematic Review
Jo Yi Chow, et al.
September 30, 2025, medRxiv
Transarterial Embolization Versus Hemispherectomy in Infants with Hemimegalencephaly and Drug-Resistant Epilepsy
Shani Israel, et al.
September 30, 2025, Pediatric Research
Integrating Price Benchmarks and Comparative Clinical Effectiveness to Predict Initial Price Offers for Medicare Drug Price Negotiation (IPAY 2027)
Kevin H. Li, PharmD, MSc, Emma M. Cousin, PharmD, Nico Gabriel, MA, Sean D. Sullivan, BScPharm, PhD
October 1, 2025, Value in Health
Evidence on Oral Tranexamic Acid Versus Intravenous Tranexamic Acid for Perioperative Blood Management in Total Knee Arthroplasty: A Systematic Review and Meta-Analysis
Yongjian Wang, et al.
October 1, 2025, EFORT Open Reviews
Robotic-Assisted vs Video-Assisted Thoracoscopic Lobectomy for Non-Small Cell Lung Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials on Surgical Quality, Perioperative, and Oncologic Outcomes
Wajahat Mirza, et al.
October 1, 2025, Journal of Robotic Surgery